| Health / Medical Topics |
GFAP wt Allele
Human GFAP wild-type allele is located in the vicinity of 17q21and is approximately 10 kb in length. This allele, which encodes glial fibrillary acidic protein, may play a role in the modulation of both motility and cellular morphology of astrocytes. Mutations in the gene are associated with Alexander disease, which is characterized by both progressive leukoencephalopathy and loss of neuronal myelination with age. (NCI Thesaurus)
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This gene may be involved in the regulation of astrocyte morphology and function.
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