Giant cell tumor

Pronunciation

Definition 1

A rare tumor that usually forms in bone, but may also form in cartilage, muscle, fat, blood vessels, or other supportive tissue in the body. Most giant cell tumors occur at the ends of the long bones of the arms and legs, near a joint (such as the knee, wrist, hip, or shoulder). Most are benign (not cancer) but some are malignant (cancer). Giant cell tumors usually occur in young and middle-aged adults. Also called GCT. (NCI Dictionary)

Definition 2

A benign or malignant connective and soft tissue tumor, characterized by the presence of multinucleated osteoclast-like giant cells. Representative examples include the giant cell tumor of bone and the giant cell tumor of tendon sheath. (NCI Thesaurus)

Definition 3

A neoplasm of bone comprised of giant cells (osteoclast-like) and mononuclear cells, for which the malignancy status has not been established. (NCI Thesaurus/CDISC)

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