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GLUTAMINE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A crystalline amino acid occurring in proteins; important in protein metabolism
Classified under:
Hypernyms ("glutamine" is a kind of...):
amino acid; aminoalkanoic acid (organic compounds containing an amino group and a carboxylic acid group)
Context examples:
A radioconjugate and glutamine analog consisting of the fluorine F 18 labeled 2S, 4R stereoisomer of 4-fluoroglutamine with potential use as a metabolic tracer for tumor imaging.
(Fluorine F 18 4-L-fluoroglutamine (2S,4R), NCI Thesaurus)
Glutamic acid-to-glutamine conversion, in which an ammonia group is added to glutamic acid (catalyzed by glutamine synthase), is of central importance in the regulation of toxic levels of ammonia in the body.
(Glutamine, NCI Thesaurus)
This species is non-spore forming, indole and glutamine decarboxylase negative, hydrolyzes esculin, and does not reduce nitrate.
(Fusobacterium necrogenes, NCI Thesaurus)
An antineoplastic-antibiotic diazo analog of L-glutamine isolated from the bacterium Streptomyces ambofaciens.
(Azotomycin, NCI Thesaurus)
When co-administered with alkylating agent melphalan, which utilizes amino acid transport systems for cellular uptake, depletion of glutamine by AGA appeared to facilitate melphalan uptake and enhance its cytotoxicity.
(Glutaminase-Asparaginase, NCI Thesaurus)
This protein is involved in both glutamine metabolism and cellular respiration.
(Glutaminase Liver Isoform, Mitochondrial, NCI Thesaurus)
This agent inhibits phosphate-activated glutaminase, a key enzyme for the synthesis of releasable glutamine, depleting cells of this essential amino acid and reducing their capacity to proliferate.
(Diazooxonorleucine, NCI Thesaurus)
A modified amino acid and structural analog of glutamine.
(Acivicin, NCI Thesaurus)
A peptide, amino acid derivative, and/or organic acid extracted from blood serum, urine, or synthesized chemically, that inhibits the methylation of nucleic acids and the incorporation of L-glutamine into tumor-cell proteins.
(Antineoplaston Agent, NCI Thesaurus)
A naturally occurring serine derivative diazo compound with antineoplastic properties, Azaserine functions as a purine antagonist and glutamine analogue (glutamine amidotransferase inhibitor) that competitively inhibits pathways in which glutamine is metabolized.
(Azaserine, NCI Thesaurus)
