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gp209-2M Antigen
Definition 1
A modified peptide antigen derived from gp209, with potential immunomodulatory and antineoplastic activities. gp209-2M antigen (IMDQVPFSV) has a methionine substitution of threonine at position 2 of gp209 peptide (ITDQVPFSV), which is the immunogenic epitope of human melanoma tumor glycoprotein gp100. Vaccination with this peptide may evoke a cytotoxic T lymphocyte (CTL) response against tumor cells expression of the gp100 antigen. (NCI Thesaurus)
Definition 2
A peptide (short piece of protein) made from the tumor-specific antigen gp100, and used to make vaccines being studied in the treatment of melanoma. (NCI Dictionary)
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