GPHN wt Allele

Human GPHN wild-type allele is located in the vicinity of 14q23.3 and is approximately 674 kb in length. This allele, which encodes gephyrin protein, plays a role in both protein-cytoskeleton interactions and biosynthesis of the molybdenum cofactor. Mutation of the gene is associated with both molybdenum cofactor deficiency type C and startle disease. A chromosomal translocation t(11;14)(q23;q23) of this gene and the MLL gene is involved in acute myeloid leukemia. (NCI Thesaurus)

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GPHN Gene

This gene is involved in vitamin metabolism.

GPER wt Allele

Human GPER wild-type allele is located in the vicinity of 7p22.3 and is approximately 12 kb in length. This allele, which encodes…

GPER Gene

This gene plays a role in both estrogen binding and G protein-coupled receptor signaling.

GPCR Signaling Pathway

The binding of b-arrestins to agonist-occupied GPCRs coincides with the recruitment of Src family tyrosine kinases, including c-Src, Hck and c-Fgr (Src-TK),…

GPCR Desensitization Pathway

Homologous desensitization of GPCRs results from the binding of b-arrestins (b-arr) to agonist -occupied receptors following phosphorylation of the receptor by…

GPC6 wt Allele

Human GPC6 wild-type allele is located in the vicinity of 13q32 and is approximately 1181 kb in length. This allele, which encodes…