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Graft-vs-Leukemia Effect
Definition 1
an advantageous side-effect of a graft-vs-host reaction in which a leukemia patient is first irradiated to kill residual leukemic cells and is then given a bone marrow graft to replenish the immune system. If cytotoxic T cells are not depleted from the bone marrow graft, these alloreactive T cells can attack the host's cells (graft-vs-host reaction) but can also attack the host's residual leukemic cells, thereby assisting in preventing recurrence of disease. (NCI Thesaurus)
Definition 2
Immunological rejection of leukemia cells following bone marrow transplantation. (NLM, Medical Subject Headings)
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