Health / Medical Topics

    Growth Factor Receptor

    Definition 1

    A class of cell surface proteins that bind to extracellular polypeptide molecules triggering intracellular signaling pathways that activate various cellular responses such as cell proliferation and/or differentiation. (NCI Thesaurus)

    Definition 2

    many of these are the gene products of protooncogenes (e.g. erbB, neu, fms) whose coupling is via a tyrosine kinase domain on the cytoplasmic end of the receptor molecule. (NIH CRISP Thesaurus)




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