| Health / Medical Topics |
GW776/5-Fluorouracil Combination Tablet
A tablet formulation containing 5-ethynyluracil (GW776), an ethynyl derivative of uracil and the antineoplastic agent 5-Fluorouracil (5-FU) in a 10:1 ratio. The GW776 portion of the tablet inhibits dihydropyrimidine dehydrogenase (DPD), the rate-limiting enzyme in 5-FU catabolism, thereby blocking degradation of 5-FU in the gastrointestinal tract and increasing the bioavailability of 5-FU. (NCI Thesaurus)
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