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HALF-LIFE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
The time required for something to fall to half its initial value (in particular, the time for half the atoms in a radioactive substance to disintegrate)
Synonyms:
half-life; half life
Classified under:
Nouns denoting time and temporal relations
Hypernyms ("half-life" is a kind of...):
period; period of time; time period (an amount of time)
Context examples:
Upon administration, the prodrug emitefur is converted into 5-FU, while CNDP prevents the degradation of 5-FU by inhibiting DPYD and thereby prolonging the half-life of 5-FU.
(Emitefur, NCI Thesaurus)
The drug half-life that quantifies the accumulation ratio of a drug following multiple dosing.
(Effective Half-life, NCI Thesaurus/CDISC)
Compared to other coumarin derivatives, acenocoumarol has a short half-life.
(Acenocoumarol, NCI Thesaurus)
The parent drug and metabolites are mainly excreted in the urine and its half-life is about 1.5 hours.
(Nateglinide, NCI Thesaurus)
Pegylation increases the half-life of this agent.
(PEG-linked L-RNA Oligonucleotide Hepcidin-targeting Agent NOX-H94, NCI Thesaurus)
With a half-life of 17 days, palladium 103 administered with brachytherapy allows continuous, tumor-site specific low-energy irradiation to the tumor cell population while sparing normal adjacent tissues from radiotoxicity.
(Palladium Pd-103, NCI Thesaurus)
Compared to other sulfonylureas, chlorpropamide has an increased risk of prolonged hypoglycemia because of its long half-life.
(Chlorpropamide, NCI Thesaurus)
Its long half-life enables it to be administered once daily.
(Piroxicam, NLM, Medical Subject Headings)
ADI is coupled to PEG in order to enhance this agent's half-life.
(Pegylated arginine deiminase, NCI Thesaurus)
Armodafinil has a longer half-life than modafinil.
(Armodafinil, NCI Thesaurus)
