Heparin Derivative SST0001

An N-acetylated, glycol-split form of heparin that is devoid of anticoagulant activity and is an inhibitor of heparanase with antineoplastic and antiangiogenic activities. Upon subcutaneous administration, heparin derivative SST0001 inhibits the activity of heparanase. This prevents the heparanase-mediated cleavage of heparan sulfate (HS) proteoglycans on cell surfaces and within the extracellular matrix. In addition, this agent prevents the heparanase-induced production of a number of angiogenic growth factors, including matrix metalloproteinase-9, hepatocyte growth factor and vascular endothelial growth factor. Altogether, this leads to an inhibition of both tumor cell growth and angiogenesis. Heparanase, an enzyme that is responsible for the proteolytic cleavage of proteoglycans, is upregulated in a variety of tumor cell types and promotes tumor cell growth; it plays a key role in tumor cell invasion, metastasis and angiogenesis. (NCI Thesaurus)

YOU MAY ALSO LIKE

Heparin Calcium

The calcium salt form of heparin. As a glycosaminoglycan anticoagulant, heparin calcium binds to antithrombin III to form a heparin-antithrombin III…

Heparin Binding Growth Factor

Exhibiting high affinity for heparin, Heparin-Binding Growth Factors (HBGF) control proliferation and differentiation of mesenchymal, epithelial, and neuroectodermal cells. Heparin may store…

Heparin Binding

Heparin Binding involves a biophysical interaction between a biological molecule, such as a protein, and heparin, a sulfated glycosaminoglycan of mixed polysaccharide…

Heparin

A substance that slows the formation of blood clots. Heparin is made by the liver, lungs, and other tissues in the body…

Heparanase-2

Heparanase-2 (592 aa, ~67 kDa) is encoded by the human HPSE2 gene. This protein is involved in the proteolysis of heparan sulfate…

Heparanase

Heparanase (543 aa, ~61 kDa) is encoded by the human HPSE gene. This protein plays a role in proteoglycan catabolism.