| Health / Medical Topics |
HER2Bi-Armed Activated T Cells
Activated T cells (ATC) that have been coated with bispecific antibodies (BiAb), with potential antineoplastic and immunomodulating activities. In vitro, T cells are activated through exposure to the anti-CD3 murine monoclonal antibody OKT3 and interleukin 2 for 14 days and then armed with anti-CD3 x anti-Her2 bispecific antibody (Her2Bi). Upon administration, HER2Bi-armed activated T cells attach to CD3-expressing T cells and HER2/neu-expressing tumor cells, selectively cross-linking T cells and tumor cells; this may result in the recruitment and activation of cytotoxic T lymphocyte (CTLs), CTL perforin-mediated tumor cell cytolysis, and the secretion of antitumor cytokines and chemokines. (NCI Thesaurus)
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A laboratory test that measures the amount of HER2/neu protein on cancer cells or how many copies of the HER2 gene are…
The result of the HER2/Neu test is not known or the test has not been performed.
The presence or absence of Her2/Neu on a tissue sample.
A laboratory test result indicating the presence of HER2/Neu in a tissue sample.
The absence of detectable HER2/Neu in a tissue sample.
A protein involved in normal cell growth. It is found on some types of cancer cells, including breast and ovarian. Cancer…
