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HISTIDINE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
An essential amino acid found in proteins that is important for the growth and repair of tissue
Classified under:
Hypernyms ("histidine" is a kind of...):
essential amino acid (an amino acid that is required by animals but that they cannot synthesize; must be supplied in the diet)
Context examples:
Tetrahydrofolate is the cofactor in the final step converting histidine to glutamate.
(Arginine, Histidine, Glutamate, Glutamine, and Proline Degradation Pathway, NCI Thesaurus/BIOCARTA)
Containing perfectly conserved histidine and cysteines residues. the BIR domain is about 70 residues long arranged in tandem repeats separated by a linker of variable length.
(BIR Domain, NCI Thesaurus)
In (H115D)VHL35 peptide, histidine is substituted for an aspartic acid in position 115.
((H115D)VHL35 Peptide, NCI Thesaurus)
Histamine Degradation consists of conjugation, transport, oxidation, or enzymatic breakdown of a decarboxylation product of histidine (histamine), found particularly in mast cells and basophils, and involved in capillary dilation and permeability; blood pressure decrease; smooth muscle contraction; gastric secretion; heart rate acceleration; immediate hypersensitivity; and central neurotransmission.
(Histamine Degradation, NCI Thesaurus)
Once inside target T cells, the DT moiety catalyzes the transfer of the ADP-ribose moiety of NAD to diphthamide, a posttranslationally modified histidine residue found in elongation factor 2 (EF-2); inactivation of EF-2, disruption of polypeptide chain elongation, and cell death ensue.
(Anti-CD3 Immunotoxin A-dmDT390-bisFv(UCHT1), NCI Thesaurus)
After the toxin moiety is internalized into target IL-2 receptor-expressing cells, its catalytic domain catalyzes the transfer of the ADP-ribose moiety of NAD to a posttranslationally modified histidine residue of elongation factor 2 (EF-2), called diphthamine.
(Denileukin diftitox, NCI Thesaurus)
Histamine Production consists of synthesis of a decarboxylation product of histidine (histamine), found particularly in mast cells and basophils, and involved in capillary dilation and permeability; blood pressure decrease; smooth muscle contraction; gastric secretion; heart rate acceleration; immediate hypersensitivity; and central neurotransmission.
(Histamine Production, NCI Thesaurus)
The lipid emulsion portion contains soybean oil, medium-chain triglycerides, olive oil and fish oil; the amino acid solution contains alanine, arginine, glycine, histidine, leucine, isoleucine, lysine, methionine, phenylalanine, proline, serine, taurine, threonine, tryptophan, tyrosine, and valine.
(Electrolyte-free Parenteral Nutrition Emulsion, NCI Thesaurus)
This protein plays a role in the biosynthesis of histamine from histidine.
(Histidine Decarboxylase, NCI Thesaurus)
Arginine and histidine contain 5 adjacent carbons and a sixth carbon attached through a nitrogen atom.
(Arginine, Histidine, Glutamate, Glutamine, and Proline Degradation Pathway, NCI Thesaurus/BIOCARTA)
