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HISTONE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A simple protein containing mainly basic amino acids; present in cell nuclei in association with nucleic acids
Classified under:
Hypernyms ("histone" is a kind of...):
simple protein (a protein that yields only amino acids when hydrolyzed)
Context examples:
Calcineurin has been shown to dephosphorylate a number of phosphoproteins including histones, myosin light chain, and the regulatory subunit of cAMP-dependent protein kinase.
(Calcineurin, NLM, Medical Subject Headings)
It belongs to the family of drugs called histone deacetylase inhibitors.
(MS-275, NCI Dictionary)
This gene is involved in both the deubiquitination of histone 2A and transcriptional regulation.
(MYSM1 Gene, NCI Thesaurus)
This allele, which encodes histone H2A deubiquitinase MYSM1 protein, plays a role in histone 2A deubiquitination and chromatin remodeling.
(MYSM1 wt Allele, NCI Thesaurus)
This protein is involved in transcription that is regulated by modifications for both DNA and histones.
(Methyl-CpG-Binding Domain Protein 3, NCI Thesaurus)
This allele, which encodes parafibromin protein, plays a role in the modulation of both RNA polymerase II-directed transcription and histone methylation.
(CDC73 wt Allele, NCI Thesaurus)
It is an inhibitor of histone deacetylase.
(Carboxycinnamic Acid Bishydroxamide, NCI Thesaurus)
One target of CARM1 is the core histones H3 and H4, which are also targets of the histone acetylase activity of CBP/p300 coactivators.
(CARM1 Transcription Regulation Pathway, NCI Thesaurus/BIOCARTA)
Histone H3 interacts with the condensin complex, and is phosphorylated during mitosis.
(AKAP8 in Mitosis Pathway, NCI Thesaurus/BIOCARTA)
In addition, the butyrate moiety inhibits histone deacetylase, which results in hyperacetylation of histones H3 and H4.
(Arginine butyrate, NCI Thesaurus)
