HL-60/MX2

HL-60/MX2 is a mitoxantrone resistant derivative of the HL-60 cell line. HL-60/MX2 is approximately 35 fold less sensitive to mitoxantrone than the HL-60 parental cells. HL-60/MX2 cells are cross-resistant to etoposide, teniposide, bisantrene, dactinomycin, 4'-(9-acridinylamino)methane- sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin. In addition, the HL-60/MX2 cells display slight collateral sensitivity to bleomycin. Resistance to mitoxantrone is stable for up to six months. (NCI Thesaurus)

YOU MAY ALSO LIKE

HL-60/MX1

HL-60/MX1 is a mitoxantrone resistant derivative of the HL-60 cell line. The cells were selected and subcloned in 1987 for resistance to…

HK2 wt Allele

Human HK2 wild-type allele is located within 2p13 and is approximately 61 kb in length. This allele, which encodes hexokinase-2 protein, plays…

HK2 Gene

This gene plays a role in carbohydrate metabolism and cell cycle progression.

HK/SING Zebrafish

A wild-type zebrafish line that is extinct.

HK/AB Zebrafish

A wild-type zebrafish line that is a hybrid of the Hong Kong and AB wild-type lines.

HIVgP160 Vaccine

A synthetic HIV vaccine based on a recombinant canary pox virus vector expressing the human immunodeficiency virus (HIV) glycoprotein gp160. HIVgP160…