HMGN Family Protein

The high mobility group N (HMGN) proteins are a family of nuclear proteins that binds to nucleosomes, changes the architecture of chromatin, and enhances transcription and replication from chromatin templates. They typically contain an NBD (Nucleosome Binding Domain) motif, which anchors these HMG proteins to the nucleosome cores to facilitate HMG-14/-17-dependent changes in higher order chromatin structure. The intracellular organization of the HMGN (previously known as HMG-14/17) proteins is dynamic and is related to both cell-cycle and transcriptional events. These proteins roam the nucleus, perhaps as part of multiprotein complexes, and their target interactions are modulated by posttranslational modifications. Functional studies on HMGN proteins provide insights into the molecular mechanisms by which structural proteins affect DNA-dependent activities in the context of chromatin. (Trends Biochem Sci 2001 Jul;26(7):431-7) (NCI Thesaurus)

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