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HYPERSENSITIVITY REACTION
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
An inappropriate and excessive reaction to an allergen (as pollen or dust or animal hair or certain foods); severity ranges from mild allergy to severe systemic reactions leading to anaphylactic shock
Classified under:
Nouns denoting stable states of affairs
Hypernyms ("hypersensitivity reaction" is a kind of...):
hypersensitivity (pathological sensitivity)
Hyponyms (each of the following is a kind of "hypersensitivity reaction"):
hives; nettle rash; urticaria; urtication (an itchy skin eruption characterized by weals with pale interiors and well-defined red margins; usually the result of an allergic response to insect bites or food or drugs)
allergic reaction; allergy (hypersensitivity reaction to a particular allergen; symptoms can vary greatly in intensity)
anaphylaxis (hypersensitivity reaction to the ingestion or injection of a substance (a protein or drug) resulting from prior contact with a substance)
allergic rhinitis (rhinitis caused by an allergic reaction)
Context examples:
A hypersensitivity reaction characterized by the sudden appearance of symmetrical cutaneous and mucocutaneous macular or papular lesions which evolve into lesions with bright red borders (target lesions).
(Erythema Multiforme, NCI Thesaurus)
This permits the administration of larger doses of docetaxel and improves the drug's safety profile by avoiding solvent-associated toxicities, such as hypersensitivity reactions and neurotoxicity.
(Nanosomal Docetaxel Lipid Suspension, NCI Thesaurus)
Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, these cells are associated with delayed-type hypersensitivity reactions.
(Murine Th1 Cells, NCI Thesaurus)
Nedocromil inhibits the activation and release of inflammatory mediators (leukotrienes, histamine and prostaglandins) from a variety of cells involved in hypersensitivity reactions, including mast cells, eosinophils, neutrophils, macrophages, monocytes and platelets.
(Nedocromil Calcium, NCI Thesaurus)
Nedocromil sodium inhibits the activation and release of inflammatory mediators (leukotrienes, histamine and prostaglandins) from a variety of cells involved in hypersensitivity reactions, including mast cells, eosinophils, neutrophils, macrophages, monocytes and platelets.
(Nedocromil Sodium, NCI Thesaurus)
The Erwinia-derived product is often used for those patients who have experienced a hypersensitivity reaction to the E. Coli formulation.
(asparaginase Erwinia chrysanthemi, NCI Thesaurus)
The vitamin-E based emulsion allows bolus infusion without steroid premedication and may diminish hypersensitivity reactions.
(Paclitaxel Vitamin E-Based Emulsion, NCI Thesaurus)
Delayed hypersensitivity reaction (DTH) - type IV reaction, an inflammatory response that develops 24 to 72 hours after exposure to an antigen that the immune system recognizes as foreign.
(Delayed-Type Hypersensitivity, NCI Thesaurus)
Systemic anaphylaxis is the most dramatic example of an immediate hypersensitivity reaction; is uncommon and unexpected in nature and occasionally results in a fatal outcome.
(Anaphylactic shock, Food and Drug Administration)
A potentially life-threatening hypersensitivity reaction to a pharmacologic substance that is characterized by rash, lymphadenopathy, fever, hematologic abnormalities and involvement of one or more internal organs.
(Drug Hypersensitivity Syndrome, NCI Thesaurus)
