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IMMUNOGENICITY
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
The property of eliciting an immune response
Classified under:
Nouns denoting stable states of affairs
Hypernyms ("immunogenicity" is a kind of...):
immunity; resistance ((medicine) the condition in which an organism can resist disease)
Derivation:
immunogenic (possessing the ability to elicit an immune response)
Context examples:
HLA-A*0201 is an MHC class I molecule that presents antigenic peptides to CD8+ T cells; epitope design restricted to epitopes that bind most efficiently to HLA-A*0201 may improve antigenic peptide immunogenicity.
(CMVpp65-A*0201 Peptide Vaccine, NCI Thesaurus)
Due to poor immunogenicity of GD3, anti-Id MoAb BEC2 (Ab2) was raised against a mouse anti-GD3 MoAb, R24 (Ab1).
(Anti-idiotypic Monoclonal Antibody BEC2, NCI Thesaurus)
DNP conjugation may enhance the immunogenicity of weakly immunogenic antigens.
(Autologous Dinitrophenyl-Modified Ovarian Cancer Vaccine, NCI Thesaurus)
A laboratory procedure where the gene encoding a therapeutic recombinant protein is manipulated to minimize the immunogenicity of the protein.
(Deimmunization, NCI Thesaurus)
PEP223 is dimerized and contains a D-lysine (k) substitution at position 6 (pyroEHWSYkLRPG) to increase its immunogenicity.
(Anti-GnRH Vaccine PEP223, NCI Thesaurus)
Dinitrophenyl compound is commonly used to couple with peptides in vaccine preparation to enhance the immunogenicity of otherwise weak immunogenic antigens.
(Dinitrophenyl, NCI Thesaurus)
A pegylated form of glutaminase-asparaginase developed to decrease immunogenicity.
(PEG-Glutaminase-Asparaginase, NCI Thesaurus)
Used in various immunologic preparations to improve immunogenicity, aluminum hydroxide adjuvant consists of aluminum hydroxide gel in a saline solution.
(Aluminum Hydroxide, NCI Thesaurus)
HLA-A2 is an MHC class I molecule that presents antigenic peptides to CD8+ T cells; epitope design restricted to epitopes that bind most efficiently to HLA-A2 may improve antigenic peptide immunogenicity.
(HLA-A2-Binding TYR/MART-1/gp100 Multipeptide-Pulsed Autologous Dendritic Cell Vaccine, NCI Thesaurus)
The advantage of using MoAb 48.7 Fab fragments over whole antibodies is that they have reduced immunogenicity, better penetration of tissues, rapid clearance from the body and that they do not induce precipitation.
(Monoclonal Antibody 48.7 F(ab), NCI Thesaurus)
