Integrin

Definition 1

Integrins are transmembrane glycoprotein receptors that mediate cell-matrix or cell-cell adhesion, and transduce signals that regulate gene expression and cell growth. They are heterodimeric molecules consisting of noncovalently linked alpha and beta subunits. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Both alpha and beta subunits display a cytoplasmic domain that interacts with the cytoskeleton (and possibly signaling molecules), a transmembrane region, and a large extracellular domain that interacts with the extracellular matrix. (from OMIM 147557) (NCI Thesaurus)

Definition 2

family of integral membrane proteins which serve as receptors for fibronectin, laminin, and other adhesive extracellular glycoproteins. (NIH CRISP Thesaurus)

YOU MAY ALSO LIKE

Integrator Complex Subunit 6

Integrator complex subunit 6 (887 aa, ~100 kDa) is encoded by the human INTS6 gene. This protein is involved in the synthesis…

Integrative medicine

A type of medical care that combines conventional (standard) medical treatment with complementary and alternative (CAM) therapies that have been shown to…

Integration Type

Location of the integration of the engineered gene e.g. random or targeted.

Integration

An operation used in calculus whereby the integral of a function is determined.

Integrated Pain Scale

An instrument designed to take into account both pain intensity and duration. (Ventafridda 1983)

Integrated Molecular Analysis of Genomes and their Expression Consortium

A group formed in 1993 by four academic groups on a collaborative basis after informal discussions led to a common vision of…