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Intercellular Adhesion Molecule 1
Definition 1
LFA-1 is a receptor for ICAM1, a surface molecule constitutively expressed on some tissues and induced on others in inflammation. The interaction of LFA-1 with ICAM provides essential accessory adhesion signals in many immune interactions, including those between T- and B-lymphocytes and cytotoxic T-cells and their targets. (NCI Thesaurus)
Definition 2
Similar to NCAM, ICAM-1 is a ligand for LFA antigens with a role in leukocyte adhesion and inflammation. Its production in a variety of cells is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue. ICAM-1 protein is the major human rhinovirus receptor. (from OMIM 147840 and NCI) (NCI Thesaurus)
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