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INTERNALIZATION
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I. (noun)
Sense 1
Meaning:
Learning (of values or attitudes etc.) that is incorporated within yourself
Synonyms:
incorporation; internalisation; internalization
Classified under:
Nouns denoting cognitive processes and contents
Hypernyms ("internalization" is a kind of...):
acquisition; learning (the cognitive process of acquiring skill or knowledge)
Hyponyms (each of the following is a kind of "internalization"):
introjection ((psychology) unconscious internalization of aspects of the world (especially aspects of persons) within the self in such a way that the internalized representation takes over the psychological functions of the external objects)
introjection ((psychoanalysis) the internalization of the parent figures and their values; leads to the formation of the superego)
Derivation:
internalize (incorporate within oneself; make subjective or personal)
Context examples:
After internalization, the DM1 moiety binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics and inhibiting cell division and the proliferation of cancer cells that express the EGFRvIII mutant.
(Anti-EGFRvIII Antibody Drug Conjugate AMG 595, NCI Thesaurus)
After internalization and proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and induces apoptosis in nectin-4 overexpressing tumor cells.
(Anti-nectin-4 Monoclonal Antibody-Drug Conjugate AGS-22M6E, NCI Thesaurus)
Multivalent Fab' antibody fragments may exhibit improved retention and internalization properties compared to their parent IgGs.
(Pegylated Anti-GFR Antibody Fragment, NCI Thesaurus)
Upon binding and internalization, oxaliplatin is released and its active derivatives alkylate macromolecules, forming both inter- and intra-strand platinum-DNA crosslinks, which results in an inhibition of DNA replication and transcription.
(Oxaliplatin-Encapsulated Transferrin-Conjugated N-glutaryl Phosphatidylethanolamine Liposome, NCI Thesaurus)
After internalization of the drug conjugate and proteolytic cleavage of the linker, MMAE binds to tubulin and inhibits its polymerization, which results in G2/M-phase growth arrest and tumor cell apoptosis.
(MUC16-targeted Antibody-Drug Conjugate DMUC5754A, NCI Thesaurus)
Upon intravenous administration, the monoclonal antibody moiety of AGS15E binds to SLITRK6 expressed on tumor cells, which facilitates both AGS15E internalization and the intracellular delivery of MMAE.
(Anti-SLITRK6 Monoclonal Antibody-MMAE Conjugate AGS15E, NCI Thesaurus)
Upon administration and internalization by LIV-1-positive tumor cells, anti-LIV-1 antibody-drug conjugate SGN-LIV1A undergoes enzymatic cleavage to release MMAE into the cytosol.
(Anti-LIV-1 Monoclonal Antibody-MMAE Conjugate SGN-LIV1A, NCI Thesaurus)
After internalization, the mertansine moiety binds to tubulin and interferes with microtubule assembly/disassembly dynamics.
(Anti-EGFR TAP Antibody-drug Conjugate IMGN289, NCI Thesaurus)
Upon internalization, DT catalyzes ADP ribosylation of elongation factor 2 (EF-2) which may result in the irreversible inhibition of protein synthesis and cell death in CD19- and CD22-expressing tumor cells.
(Anti-CD19/Anti-CD22 Bispecific Immunotoxin DT2219ARL, NCI Thesaurus)
Upon internalization, calicheamicin, an enediyne class antibiotics, is released from the conjugate by hydrolysis, and binds in a sequence specific manner to the minor groove of DNA.
(Anti-CD33 Immunotoxin, NCI Thesaurus)
