Iobenguane I-123

Definition 1

An iodine (I) 123 labeled aralkylguanidine norepinephrine analogue used as a diagnostic imaging tracer. Iobenguane, structurally related to norepinephrine, functioning as a false substrate of norepinephrine, and is taken up and localized in the granules of pre-synaptic adrenergic neurons. When labeled with I-123, this agent is useful for the imaging of neuroendocrine tissues and tumors. (NCI Thesaurus)

Definition 2

A substance used to detect certain types of tumors, including pheochromocytomas and neuroblastomas. It contains a substance called iobenguane linked to a radioactive substance called iodine I 123. The tumor cells take up the iobenguane I 123, and a machine is used to detect where the cancer cells are in the body. It is a type of radioimaging agent. (NCI Dictionary)

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