Itolizumab

A humanized IgG1 monoclonal antibody targeting the T-cell differentiation antigen CD6, with immunmodulating activity. Itolizumab binds to CD6, downregulates the activation and differentiation of T cells, prevents CD6-mediated activation pathways and reduces the synthesis of pro-inflammatory cytokines. CD6, a co-stimulatory molecule predominantly expressed on lymphocytes, is involved in the adhesion and maturation of T cells. (NCI Thesaurus)

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Ito Cell Tumor

A benign or malignant tumor of the liver composed of hepatic stellate cells.

ITK wt Allele

Human ITK wild-type allele is located within 5q31-q32 and is approximately 74 kb in length. This allele, which encodes tyrosine-protein kinase ITK/TSK…

ITK Gene

This gene is involved in the differentiation and proliferation of T cells.

ITIM

ITIM (immunoreceptor Tyr-based inhibition motif) (I/V-X-Y-X-X-L), a protein domain involved in STP, binds to SH2 domain in SHP1 and SHP2, e.g., in…

ITGB7 wt Allele

Human ITGB7 wild-type allele is located in the vicinity of 12q13.13 and is approximately 16 kb in length. This allele, which encodes…

ITGB7 Gene

This gene plays a role in both cell-matrix adhesion and integrin-mediated signaling.