Library / English Dictionary

KETAMINE

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

A general anesthetic and tranquilizer (not a barbiturate) that is administered intravenously or intramuscularly; used mainly by veterinarians or for minor surgery with geriatric or pediatric patients; taken in large doses it causes hallucinations similar to those associated with the use of PCP

Synonyms:

Ketalar; ketamine; ketamine hydrochloride

Classified under:

Nouns denoting man-made objects

Hypernyms ("ketamine" is a kind of...):

club drug (a controlled substance that is usually taken by young people at dance clubs and raves)

general anaesthetic; general anesthetic (an anesthetic that anesthetizes the entire body and causes loss of consciousness)

Hyponyms (each of the following is a kind of "ketamine"):

cat valium; green; honey oil; jet; K; special K; super acid; super C (street names for ketamine)

Credits

 Context examples: 

Also called baclofen/amitriptyline/ketamine gel.

(BAK gel, NCI Dictionary)

Although its mechanism of action is not well understood, ketamine appears to non-competitively block N-methyl-D-aspartate (NMDA) receptors and may interact with opioid mu receptors and sigma receptors, thereby reducing pain perception, inducing sedation, and producing dissociative anesthesia.

(Ketamine hydrochloride, NCI Thesaurus)

In other words, ketamine had blocked the effects of over-activating area 25, which would otherwise blunt anticipation.

(Marmoset study gives insights into loss of pleasure in depression, University of Cambridge)

Ketamine inhibits biogenic amine uptake, agonistically binds to mu-opioid receptors, and inhibits NMDA receptors.

(Ketamine/Amitriptyline NP-H Cream, NCI Thesaurus)

Also called Ketalar and ketamine hydrochloride.

(Ketamine, NCI Dictionary)

A topical preparation of baclofen, amitriptyline, and ketamine compounded in a penetration-enhancing polaxamer-lecithin organogel (PLO) with potential antineuralgic activity.

(Baclofen/amitriptyline/ketamine gel, NCI Thesaurus)

Also called Ketalar and ketamine.

(Ketamine hydrochloride, NCI Dictionary)

Although its mechanism of action is not well understood, ketamine appears to non-competitively block N-methyl-D-aspartate (NMDA) receptors and agonistically bind to and activate opioid mu and sigma receptors, thereby reducing pain perception, inducing sedation, and producing dissociative anesthesia.

(Intranasal Ketamine, NCI Thesaurus)

In a study involving marmosets, scientists at the University of Cambridge have identified the region of the brain that contributes to this phenomenon, and shown that the experimental antidepressant ketamine acts on this region, helping explain why this drug may prove effective at treating anhedonia.

(Marmoset study gives insights into loss of pleasure in depression, University of Cambridge)

NDMA receptor antagonists such as amitriptyline and ketamine interfere with the role of NMDA receptors in the process of central sensitization in which NMDA receptors on spinal dorsal horn neurons are activated, resulting in an increase in synaptic efficacy and so an amplification of the response to sensory input.

(Ketamine/Amitriptyline NP-H Cream, NCI Thesaurus)