Kinase Suppressor of RAS-1

Similar to RAS kinase suppressor (Drosophila) and encoded by human KSR Gene (SER/THR PK Family), Kinase Suppressor of RAS-1 is a positive modulator of RAS-MAP kinase signaling. KSR Homologs are found in C. elegans and mouse. The predicted 873-amino acid mouse protein contains a kinase domain similar to RAF kinases; human protein is nearly 95% similar to mouse. In unstimulated cells, CTAK1 constitutively associates with KSR1, phosphorylating Ser392 and conferring cytoplasmic sequestration by 14-3-3 binding. In response to growth factor, KSR1 Ser392 phosphorylation falls, allowing KSR1 to localize with activated RAS and RAF1 at the plasma membrane and facilitating phosphorylation required for activation of MEK and MAPK. (from LocusLink, Swiss-Prot, OMIM, and NCI) (NCI Thesaurus)

YOU MAY ALSO LIKE

Kinase Suppressor of Ras 2

Kinase suppressor of Ras 2 (950 aa, ~108 kDa) is encoded by the human KSR2 gene. This protein plays a role in…

Kinase inhibitor

A substance that blocks a type of enzyme called a kinase. Human cells have many different kinases, and they help control important…

Kinase Family Gene

Kinase Family Genes encode Kinase enzymes that covalently transfer the terminal, gamma phosphate group from ATP to a variety of substrates and…

Kinase

A type of enzyme (a protein that speeds up chemical reactions in the body) that adds chemicals called phosphates to other molecules,…

Kinaret

A substance that is used to treat rheumatoid arthritis, and is being studied in the treatment of cancer. Kinaret blocks the action…

Kimmel Cancer Center

The mission of the Kimmel Cancer Center is to make transformational discoveries of the cellular and molecular biology of the malignant process…