Ku80 Protein

KU80 protein is the 80 kD subunit of the KU autoantigen, a heterodimeric DNA repair complex that binds DNA double-strand breaks, is the DNA-binding component of the DNA-dependent protein kinase, and facilitates repair by nonhomologous end-joining. KU70 and KU80 form a dyad-symmetrical molecule with a preformed ring that encircles duplex DNA. KU protein is also involved in V(D)J recombination. KU is identical to DNA helicase II, an ATP-dependent DNA unwinding enzyme. (from OMIM 194364 and NCI) (NCI Thesaurus)

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