L-377,202

Definition 1

A substance that is being studied in the treatment of cancer. (NCI Dictionary)

Definition 2

A prodrug in which a peptide is covalently conjugated with the anthracycline antineoplastic antibiotic doxorubicin. This complex is hydrolyzed by the enzyme prostate-specific antigen (PSA), resulting in the formation of doxorubicin and leucine-doxorubicin. Selective targeting of these drugs to prostate tumor cells occurs because the hydrolyzing PSA enzyme is localized to the prostate gland. Doxorubicin and leucine-doxorubicin intercalate into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. These agents also produce toxic free-radical intermediates and interact with cell membrane lipids causing lipid peroxidation. (NCI Thesaurus)

YOU MAY ALSO LIKE

L-3,5,5’-tetraiodothyronine

A hormone that is made by the thyroid gland and contains iodine. L-3,5,5’-tetraiodothyronine increases the rate of chemical reactions in cells and…

L Antigen Family Member 3

L antigen family member 3 (143 aa, ~15 kDa) is encoded by the human LAGE3 gene. This protein has no known…

L

A measure of volume for a liquid, using the metric system. One L is equal to 1,000 cubic centimeters (cc), 1,000 milliliters…

Kytril

A drug used to prevent nausea and vomiting caused by chemotherapy and radiation therapy. It is also used to prevent nausea and…

Kytococcus sedentarius

A species of aerobic, Gram positive, cocci shaped bacteria assigned to the phylum Actinobacteria. This species is nonencapsulated, nonendosporeforming, nonmotile, catalase positive,…

Kytococcus

A genus of aerobic, Gram positive, cocci shaped bacterium assigned to the phylum Actinobacteria and the family Dermacoccaceae.