Lambert Eaton Myasthenic Syndrome

Definition 1

A rare autoimmune presynaptic disorder characterized by impairment of the impulse transmission at the neuromuscular junction. It affects predominantly the proximal muscles of the lower extremities, resulting in muscle weakness and fatigability. It has been associated with small cell lung carcinoma. (NCI Thesaurus)

Definition 2

An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471) (NLM, Medical Subject Headings)

YOU MAY ALSO LIKE

Lambda Z Time Upper Limit

The upper limit on timing values to be included in the calculation of Lambda z.

Lambda Z Time Lower Limit

The lower limit on timing values to be included in the calculation of Lambda z.

Lambda Z

The first order rate constant associated with the terminal (log-linear) portion of the curve.

Lambda Sutural Junction

The point of junction of the sagittal and lambdoid sutures of the skull.

Lambda

A mixing parameter typically giving a degree of smoothing used, or a relaxation parameter defining a rate of convergence.

LALBA wt Allele

Human LALBA wild-type allele is located in the vicinity of 12q13 and is approximately 2 kb in length. This allele, which encodes…