Laromustine

Pronunciation

Definition 1

A drug used to treat acute myelogenous leukemia (AML). It is also being studied in the treatment of several other types of cancer. It blocks cell growth by damaging the cell’s DNA and may kill cancer cells. It is a type of alkylating agent. Also called Cloretazine and Onrigin. (NCI Dictionary)

Definition 2

A sulfonyl hydrazine prodrug with antineoplastic activity. Laromustine releases the DNA chloroethylating agent 90CE after entering the blood stream; 90CE chloroethylates alkylates the O6 position of guanine, resulting in DNA crosslinking, strand breaks, chromosomal aberrations, and disruption of DNA synthesis. Intracellular metabolism of this agent also releases methyl isocyanate which inhibits O6-alkyl-guanine transferase, an enzyme involved with DNA repair. (NCI Thesaurus)

YOU MAY ALSO LIKE

Largetrifoliolious Bugbane Rhizome Supplement

A proprietary tablet formulation containing an extract from Largetrifoliolious Bugbane rhizome (Shengma), the dried root of Cimicifuga sp., with potential use for…

Largest

Greatest in size of those under consideration.

Large-Scale Sequencing

The process of determining of the precise sequence of nucleotides over a very large piece of DNA, possibly the entire genome of…

Large Unstained Cells to Leukocytes Ratio Measurement

The determination of the ratio of large unstained cells compared to leukocytes present in a sample. The measurement may be expressed as…

Large Unstained Cell Count

The determination of the number of large unstained cells present in a sample.

Large Platelet Count

The determination of the number of large platelets present in a sample.