Leptin Receptor

Encoded by human LEPR Gene (gp130 Cytokine Receptor Family), five Leptin Receptor isoforms are variously expressed in liver, hypothalamus, heart, small intestine, hematopoietic tissues, choroid plexus, prostate, ovary, lung, and kidney. Isoform E may be soluble. The 1165-amino acid 132.5-kD (precursor) type I membrane protein contains 3 fibronectin III-like domains and is TYR phosphorylated; the cytoplasmic domain appears essential for signal transduction. LEPR appears involved in regulation of fat metabolism through hypothalamic effects, angiogenesis, lymphopoiesis, and possibly reproduction. LEPR appears to activate JAK kinase and STAT3, -5, and -6. LEPR malfunction is associated with diabetes and obesity. (from LocusLink, Swiss-Prot, OMIM, and NCI) (NCI Thesaurus)

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