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LEUCINE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A white crystalline amino acid occurring in proteins that is essential for nutrition; obtained by the hydrolysis of most dietary proteins
Classified under:
Hypernyms ("leucine" is a kind of...):
essential amino acid (an amino acid that is required by animals but that they cannot synthesize; must be supplied in the diet)
Context examples:
This protein is comprised of most of the non-POU domain-containing octamer-binding protein fused to the C-terminal basic helix-loop-helix DNA binding and leucine zipper dimerization domains of the transcription factor E3 protein.
(NONO/TFE3 Fusion Protein, NCI Thesaurus)
Nrf2, a leucine zipper transcription factor, plays a key role in the maintenance of redox balance and cytoprotection against oxidative stress.
(Nrf2 Activator RTA 408, NCI Thesaurus)
A radiotracer containing a synthetic amino acid analogue of L-leucine radiolabeled with fluorine F 18 with potential diagnostic imaging use.
(Fluciclovine (18F), NCI Thesaurus)
A proto-oncogene, identified in several avian tumors, encoding a nuclear protein with a leucine zipper motif.
(Oncogene MYC, NCI Thesaurus)
An orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.
(MELK Inhibitor OTS167, NCI Thesaurus)
This protein is comprised of the transactivation domain of the RNA-binding protein EWS followed by the DNA-binding basic domain and leucine zipper dimerization domain of the cyclic AMP-dependent transcription factor ATF-1 protein.
(EWSR1/ATF1 Fusion Protein, NCI Thesaurus)
Upon oral administration of beta-hydroxy-beta-methylbutyrate (HMB), this leucine metabolite may decrease protein breakdown and increase protein synthesis thereby increasing muscle strength and mass.
(Beta-hydroxy-beta-methylbutyrate Supplement, NCI Thesaurus)
Bipartite DNA binding domain containing a basic region directly interacting with DNA, and a leucine zipper mediating dimerization through contacts with a protein partner.
(bZIP Domain, NCI Thesaurus)
The scientists now are planning a study to assess the effect of supplemental glutamine and leucine, another amino acid that activates mTORC1, in people with atopic dermatitis with and without CARD11 mutations.
(Scientists identify single-gene mutations that lead to atopic dermatitis, National Institutes of Health)
This species is leucine arylamidase positive, lipase and trypsin negative, nonsporulating, non-motile, produces acid from ribose, glucose, mannose, cellobiose and salicin but not from maltose, lactose, trehalose, esculin or amygdalin.
(Collinsella intestinalis, NCI Thesaurus)
