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Linsitinib
Definition 1
An orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGF-1R stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis. (NCI Thesaurus)
Definition 2
A substance being studied in the treatment of cancer. It blocks a protein called IGF-1R, which is found at high levels in some types of tumors. IGF-1R is needed for cell growth and blocking it may cause tumor cells to die. IGF-1R inhibitor OSI-906 is a type of IGF-1R inhibitor. (NCI Dictionary)
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