LobuloAlveolar Mouse MIN

Definition 1

A focus of residual alveoli that persist in the mouse mammary gland following hormone stimulation (NCI Thesaurus/MMHCC)

Definition 2

The HAN (hyperplastic alveolar nodule) is the prototypical Lobuloalveolar lesion. The HAN is a focal area with closely packed acini with slightly atypical nuclei (NCI Thesaurus/MMHCC)

Definition 3

The HAN has been proven to be pre-neoplastic (premalignant) by serial transplantation into the gland-cleared fat pad of syngeneic mice. The serial transplantation proves that the HAN is immortal (NCI Thesaurus/MMHCC)

Definition 4

The hyperplastic outgrowths of HAN transplants undergo a high rate of malignant transformation proving their risk of undergoing malignant transformation. The HAN will not grow or become malignant if it is transplanted into the subcutaneous tissue (NCI Thesaurus/MMHCC)

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