Lubiprostone

A bicyclic fatty acid derived from prostaglandin E1 and a chloride channel activator with laxative activity. Upon intake, lubiprostone specifically binds to and activates the type 2 chloride channel (ClC-2) in the apical membrane of the gastrointestinal epithelium. This produces an efflux of chloride ions, thereby drawing water into the gastrointestinal lumen. The resulting increased amounts of intestinal fluid soften the stool, increase motility, and improve bowel movements. (NCI Thesaurus)

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LTK wt Allele

Human LTK wild-type allele is located within 15q15.1-q21.1 and is approximately 10 kb in length. This allele, which encodes leukocyte tyrosine kinase…

LTK Gene

This gene plays a role in leukocyte tyrosine kinase signal transduction and diverse cellular regulatory pathways.

LTF wt Allele

Human LTF wild-type allele is located in the vicinity of 3p21.31 and is approximately 50 kb in length. This allele, which encodes…

LTF Gene

This gene is involved in both the transport of iron and proteolysis.