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MAST CELL
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I. (noun)
Sense 1
Meaning:
A large connective tissue cell that contains histamine and heparin and serotonin which are released in allergic reactions or in response to injury or inflammation
Synonyms:
labrocyte; mast cell; mastocyte
Classified under:
Hypernyms ("mast cell" is a kind of...):
somatic cell; vegetative cell (any of the cells of a plant or animal except the reproductive cells; a cell that does not participate in the production of gametes)
Holonyms ("mast cell" is a part of...):
connective tissue (tissue of mesodermal origin consisting of e.g. collagen fibroblasts and fatty cells; supports organs and fills spaces between them and forms tendons and ligaments)
Context examples:
Increased cAMP levels cause relaxation of bronchial smooth muscle, improve mucocliary clearance and reduce inflammatory cell mediator release, especially from mast cells.
(Metaproterenol Sulfate, NCI Thesaurus)
Doxylamine competitively inhibits the histamine 1 (H1) receptor, thereby preventing the action of endogenous histamine as well as the subsequent release of pro-inflammatory mediators from basophils and mast cells.
(Doxylamine, NCI Thesaurus)
Cromolyn sodium probably interferes with the antigen-stimulated calcium transport across the mast cell membrane, thereby inhibiting mast cell release of histamine, leukotrienes, and other substances that cause hypersensitivity reactions.
(Cromolyn Sodium, NCI Thesaurus)
A form of mastocytosis characterized by mast cell infiltration of the skin. (WHO, 2001) — 2003
(Cutaneous Mastocytosis, NCI Thesaurus)
Cells exhibit features of mast cells; Lesion has characteristic cytology: uniform, closely packed cells with round nuclei and clear abundant cytoplasm with or without granules
(Mouse Mast Cell Hematopoietic Sarcoma, NCI Thesaurus/MMHCC)
Epinastine hydrochloride blocks the histamine H1 receptor and inhibits the release of histamine from mast cells.
(Epinastine Hydrochloride, NCI Thesaurus)
Nedocromil sodium inhibits the activation and release of inflammatory mediators (leukotrienes, histamine and prostaglandins) from a variety of cells involved in hypersensitivity reactions, including mast cells, eosinophils, neutrophils, macrophages, monocytes and platelets.
(Nedocromil Sodium, NCI Thesaurus)
This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells.
(Phentolamine, NCI Thesaurus)
People with ISM have an abnormally elevated number of mast cells, an immune cell type which contributes to anaphylaxis and other allergic symptoms by releasing histamine and other chemicals that cause inflammation.
(NIAID scientists link cases of unexplained anaphylaxis to red meat allergy, National Institutes of Health)
A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages.
(Myeloproliferative Neoplasm, NCI Thesaurus)
