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MEK
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I. (noun)
Sense 1
Meaning:
A terrorist organization formed in the 1960s by children of Iranian merchants; sought to counter the Shah of Iran's pro-western policies of modernization and opposition to communism; following a philosophy that mixes Marxism and Islam it now attacks the Islamic fundamentalists who deposed the Shah
Synonyms:
MEK; MKO; Mujahidin-e Khalq Organization; People's Mujahidin of Iran
Classified under:
Nouns denoting groupings of people or objects
Instance hypernyms:
foreign terrorist organization; FTO; terrorist group; terrorist organization (a political movement that uses terror as a weapon to achieve its goals)
Domain category:
act of terrorism; terrorism; terrorist act (the calculated use of violence (or the threat of violence) against civilians in order to attain goals that are political or religious or ideological in nature; this is done through intimidation or coercion or instilling fear)
Domain region:
Iran; Islamic Republic of Iran; Persia (a theocratic Islamic republic in the Middle East in western Asia; Iran was the core of the ancient empire that was known as Persia until 1935; rich in oil)
Context examples:
MEK1/2 are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types.
(MEK Inhibitor MEK162, NCI Thesaurus)
A synthetic, fungal metabolite analogue inhibitor of mitogen-activated protein kinase kinase 1 (MEK-1) and mitogen-activated protein kinase kinase kinase 1 (MEKK-1) with potential antipsoriatic and antineoplastic activities.
(MEK-1/MEKK-1 Inhibitor E6201, NCI Thesaurus)
Raf protein kinases play a key role in the RAF/MEK/ERK signaling pathway, which is often deregulated in human cancers and plays a key role in tumor cell proliferation and survival.
(pan-RAF Kinase Inhibitor MLN2480, NCI Thesaurus)
An orally available dual inhibitor of mitogen-activated protein kinase kinase (MEK) and Aurora kinases, with potential antineoplastic activity.
(MEK/Aurora Kinase Inhibitor BI 847325, NCI Thesaurus)
MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.
(MEK Inhibitor AZD8330, NCI Thesaurus)
MEK inhibitor GDC-0623 specifically inhibits mitogen-activated protein kinase kinase (MEK or MAP/ERK kinase), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation.
(MEK Inhibitor GDC-0623, NCI Thesaurus)
MEK 1 and 2 are dual specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in various cancer cells.
(Carbon C 14 Selumetinib, NCI Thesaurus)
Raf kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are frequently upregulated in neoplasms.
(B-Raf/VEGFR-2 Inhibitor RAF265, NCI Thesaurus)
An orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase (MAP2K, MAPK/ERK kinase, or MEK) 1 and 2 with potential antineoplastic activity.
(MEK 1/2 Inhibitor AS703988/MSC2015103B, NCI Thesaurus)
“Ah, my frien’s,” he said softly, “mebbe it mek you mad dog, dose many bites. Mebbe all mad dog, sacredam! Wot you t’ink, eh, Perrault?”
(The Call of the Wild, by Jack London)
