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MELPHALAN
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I. (noun)
Sense 1
Meaning:
Antineoplastic drug (trade name Alkeran) used to treat multiple myeloma and some other malignancies
Synonyms:
Classified under:
Nouns denoting man-made objects
Hypernyms ("melphalan" is a kind of...):
antineoplastic; antineoplastic drug; cancer drug (any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function)
Context examples:
Melphalan hydrochloride is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA.
(Melphalan Hydrochloride, NCI Thesaurus)
When co-administered with alkylating agent melphalan, which utilizes amino acid transport systems for cellular uptake, depletion of glutamine by AGA appeared to facilitate melphalan uptake and enhance its cytotoxicity.
(Glutaminase-Asparaginase, NCI Thesaurus)
HL-60/MX2 cells are cross-resistant to etoposide, teniposide, bisantrene, dactinomycin, 4'-(9-acridinylamino)methane- sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin.
(HL-60/MX2, NCI Thesaurus)
Also called melphalan.
(Alkeran, NCI Dictionary)
HL-60/MX1 cells are cross resistant to etoposide, teniposide, bisantrene, actinomycin, 4'-(9-acridinylamino)methane-sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin.
(HL-60/MX1, NCI Thesaurus)
A melphalan prodrug in which the alkylating agent melphalan is bound to flufenamide, with potential antineoplastic and anti-angiogenic activities.
(Melphalan-Flufenamide Prodrug, NCI Thesaurus)
Upon administration, melphalan is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA; RNA and proteins may also be alkylated.
(Melphalan Hydrochloride/Sulfobutyl Ether Beta-Cyclodextrin Complex, NCI Thesaurus)
Melphalan alkylates DNA at the N7 position of guanine residues and induces DNA intra- and inter-strand cross-linkages.
(Melphalan-Flufenamide Prodrug, NCI Thesaurus)
A propylene glycol-free intravenous formulation containing the hydrochloride salt of the nitrogen mustard phenylalanine derivative melphalan complexed with polyanionic sulfobutyl ether beta-cyclodextrin (SBE-CD) with potential antineoplastic activity.
(Melphalan Hydrochloride/Sulfobutyl Ether Beta-Cyclodextrin Complex, NCI Thesaurus)
