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Mitotane
Pronunciation
Definition 1
An anticancer drug used in treating adrenocortical cancer and ACTH-producing pituitary tumors (Cushing disease). (NCI Dictionary)
Definition 2
A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. (NCI Thesaurus)
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