Molecule in Immune System Able to Trigger 'Suicide' of Cancerous Tumors

Researchers discovered a molecule in the immune system that could naturally kill cancer cells.

Molecule in immune system able to trigger 'suicide' of cancerous tumors. Image credit: tasnimnews.com

King's College London scientists exposed colorectal tumors to the β-galactoside-binding protein (βGBP) in the laboratory. They found the protein has 'tumor-suppressing properties', which triggered the 'suicide' of malignant cells.

βGBP is also thought to make the tumor more visible to the immune system, which then launches an anti-cancer response to prevent it returning.

Chemo, a go-to therapy for cancer, works to kill malignant cells by stopping them reproducing. This prevents tumors from growing and spreading around the body. However, chemo can cause nasty side effects, like vomiting, fatigue and hair loss. It also does not work for all patients.

"By contrast, the anti-tumor property of βGBP is selective and not harmful to normal cells," lead author Professor Livio Mallucci said. "βGBP is effective against the most aggressive colorectal cancer cells and a wide range of other cancer cells equally unresponsive to current therapies.

"This research presents experimental evidence for a strategy where the targeting of cancer cells and the stimulation of immunity combine to prompt immediate and long-term responses against aggressive cancer. "Translation of βGBP to the clinic could open a new therapeutic opportunity which safely combines direct killing of cancer cells and the stimulation of the immune system against recurrences.

βGBP is a form of immunotherapy, which works with a patient's immune system to help them fight the disease. The scientists exposed colorectal cancer cells to the 'lowest therapeutically effective dose of βGBP that induces apoptosis', or 'cell suicide'.

These cells had previously failed to respond to existing methods of 'therapeutic attack'. Within 48 hours of βGBP treatment, 'cell stress' and 'evidence' of destruction had 'fully manifest'. The same results occurred when the scientists tested βGBP in mice with the disease. The treatment also raised no safety alarms.

"As a natural component of the anti-cancer immune network, unlike pharmacological inducers which carry associated toxicity and uncertainty, beta-GBP has no harmful properties," Professor Mallucci said.

As well as helping to destroy cancer, the approach could also offer patients "long-term protection by instating cancer specific immune surveillance", the scientists wrote. (Tasnim News Agency)

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