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MONOAMINE OXIDASE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
An enzyme that catalyzes the oxidation of many body compounds (e.g., epinephrine and norepinephrine and serotonin)
Synonyms:
MAO; monoamine oxidase
Classified under:
Hypernyms ("monoamine oxidase" is a kind of...):
enzyme (any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions)
Context examples:
Aminobenzoic acid may also increase oxygen uptake at the tissue level and may enhance monoamine oxidase (MAO) activity to promote the degradation of serotonin, which in excess, may lead to fibrotic changes.
(Aminobenzoic acid, NCI Thesaurus)
In biological applications, hydrazine and its derivatives exhibit antidepressant properties by inhibiting monoamine oxidase (MAO), an enzyme that catalyzes the deamination and inactivation of certain stimulatory neurotransmitters such as norepinephrine and dopamine.
(Hydrazine, NCI Thesaurus)
Several monoamine oxidase inhibitors are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels.
(Antidepressant Agent, NLM, Medical Subject Headings)
C 11 AMS accumulates in serotonergic nerve terminals in proportion to the synthesis rate of serotonin because C 11 AMS cannot be broken down by the enzyme monoamine oxidase, and thus the synthesis rate of serotonin can be imaged using PET.
(Carbon C 11 Alpha-methyltryptophan, NCI Thesaurus)
A synthetic derivative of phenylpiperazine and chemically unrelated to selective serotonin reuptake inhibitors, tricyclics, tetracyclics, or monoamine oxidase inhibitors (MAOI), antidepressant Nefazadone Hydrochloride antagonizes central 5-HT2 receptors and inhibits reuptake of serotonin and norepinephrine.
(Nefazodone Hydrochloride, NCI Thesaurus)
