| Health / Medical Topics |
Mothers Against Decapentaplegic Homolog 3
Regulated by TGF-beta receptors, Mothers Against Decapentaplegic Homolog 3 is an effector of the TGF-beta response. MADH3 is associated with and phosphorylated by the ligand-bound receptor complex. MADH3 and MADH4 synergize to induce strong TGF-beta-like responses. SMAD3 and SMAD4 proteins specifically recognize an eight base pair palindromic DNA sequence that confers TGF-beta responsiveness to a minimal promoter. (from OMIM 603109 and NCI) (NCI Thesaurus)
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