Myelodysplastic syndrome

Pronunciation

Definition 1

A type of cancer in which the bone marrow does not make enough healthy blood cells (white blood cells, red blood cells, and platelets) and there are abnormal cells in the blood and/or bone marrow. When there are fewer healthy blood cells, infection, anemia, or bleeding may occur. Sometimes, myelodysplastic syndrome becomes acute myeloid leukemia (AML). Also called MDS. (NCI Dictionary)

Definition 2

A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (NCI Thesaurus/WHO)

Definition 3

A disorder characterized by insufficiently healthy hematapoietic cell production by the bone marrow. (NCI Thesaurus/CTCAE)

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