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Myeloproliferative Neoplasm
Pronunciation
Definition 1
A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008) (NCI Thesaurus)
Definition 2
A group of slow growing blood cancers, including chronic myelogenous leukemia, in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood. (NCI Dictionary)
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A type of disease in which the bone marrow makes too many red blood cells, platelets, or certain white blood cells. Myeloproliferative…
Myeloproliferation involves both medullary and extramedullary proliferation of bone marrow constituents, such as erythroblasts, granulocytes, megakaryocytes, and fibroblasts.
The hematopoietic process that refers to the production of myelocytes.
The determination of the amount of myeloperoxidase present in a sample.
The determination of the amount of myeloperoxidase antibody present in a sample.
Myeloperoxidase (745 aa, ~84 kDa) is encoded by the human MPO gene. This protein is involved in the regulation of the innate…
