Natriuretic Peptide Receptor B

Expressed in heart and vasculature by human NPR2 Gene (Guanylyl Cyclase Family), type I integral membrane protein Natriuretic Peptide Receptor B is the primary receptor for C-type natriuretic peptides that cause natriuresis, sodium excretion in the urine. NPR2 contains an extracellular ligand-binding domain, a membrane-spanning region, and an intracellular protein kinase homology domain, oligomerizing helical hinge region, and a C-terminal guanylyl cyclase catalytic domain activated upon receptor ligand binding. NPR2 seems to be more effectively stimulated by BNP than by ANP. NPR1 and NPR2 are ANP receptors with guanylate cyclase activity; NPR3 is probably responsible for ANP clearance from the circulation without a role in signal transduction. (NCI Thesaurus)

YOU MAY ALSO LIKE

Native Hawaiian or Other Pacific Islander

A person having origins in any of the original peoples of Hawaii, Guam, Samoa, or other Pacific Islands. (OMB)

Native Hawaiian

A person having origins in any of the original peoples of Hawaii.

Native American Health

Every racial or ethnic group has specific health concerns. Differences in the health of groups can result from:

Native American

A Native American (NA) is a person having origins in one of the indigenous peoples of North America, who lived on the…

Native

Of or related to the original state or source; natural.

National Wilms' Tumor Study Group

A group established in 1969 with goals: to improve the survival of children with Wilms tumor and other renal tumors, to study…