Nelarabine

Pronunciation

Definition 1

A drug used to treat certain types of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). It belongs to the family of drugs called antimetabolites. Also called 506U78 and Arranon. (NCI Dictionary)

Definition 2

An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. (NCI Thesaurus)

YOU MAY ALSO LIKE

NEK9 wt Allele

Human NEK9 wild-type allele is located in the vicinity of 14q24.3 and is approximately 45 kb in length. This allele, which encodes…

NEK9 Gene

This gene is involved in protein phosphorylation and cell division.

NEK3 wt Allele

Human NEK3 wild-type allele is located in the vicinity of 13q14.13 and is approximately 27 kb in length. This allele, which encodes…

NEK3 Gene

This gene plays a role in neuronal morphogenesis.

NEK10 wt Allele

Human NEK10 wild-type allele is located the vicinity of 3p24.1 and is approximately 284 kb in length. This allele, which encodes serine/threonine-protein…

NEK10 Gene

This gene plays a role in the regulation of protein phosphorylation.