Neomycin

Definition 1

A broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity. Neomycin is an antibiotic complex consisting of 3 components: the two isomeric components B and C are the active components, and neomycin A is the minor component. Neomycin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, neomycin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death. (NCI Thesaurus)

Definition 2

Antibiotic complex produced by Streptomyces fradiae. It is composed of neomycins A, B, and C. It acts by inhibiting translation during protein synthesis. (NLM, Medical Subject Headings)

YOU MAY ALSO LIKE

Neogenin

Neogenin (1461 aa, ~160 kDa) is encoded by the human NEO1 gene. This protein plays a role in muscle cell differentiation. …

Neoantigen-based Melanoma-Poly-ICLC Vaccine

A peptide-based melanoma cancer vaccine consisting of neoantigens and peptides derived from patient-specific melanoma immunogenic epitopes, combined with the immunostimulant poly-ICLC with…

Neoangiogenesis

The formation of new or recent blood vessels. The vasculature network is critical to the development of neoplasms. As the tumor burden…

Neoadjuvant therapy

Treatment given as a first step to shrink a tumor before the main treatment, which is usually surgery, is given. Examples of…

NEO1 wt Allele

Human NEO1 wild-type allele is located within 15q22.3-q23 and is approximately 253 kb in length. This allele, which encodes neogenin, plays a…

NEO1 Gene

This gene plays a role in neural differentiation and cell cycle regulation.