Neuregulin 1

Definition 1

Neuregulin-1 was first cloned as "heregulin" and "neu differentiation factor" and was initially thought to be a ligand for ErbB2, which is overexpressed in about 25% of women with breast cancer. Neuregulin-1 has also been studied as the "glial growth factor," which acts as a Schwann cell mitogen, and as "ARIA" (acetylcholine receptor inducing activity), a regulator of the expression of acetylcholine receptors. (NCI Thesaurus)

Definition 2

A peptide factor originally identified by its ability to stimulate the phosphorylation the erbB-2 receptor (RECEPTOR, ERBB-2). It is a ligand for the erbB-3 receptor (RECEPTOR, ERBB-3) and the erbB-4 receptor. Variant forms of NEUREGULIN-1 occur through alternative splicing of its mRNA. (NLM, Medical Subject Headings)

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