| Health / Medical Topics |
Neuronal SHC
Expressed in the brain by human SHC3 Gene, the 474-aa 52-kD and 594-aa 64-kD isoforms of Neuronal SHC are similar to SHC; nearly 70% homology in the PTB and SH2 domains. SHC3 appears involved in signaling from BDNF/TRKB to the RAS/MAPK pathway. BDNF induces tyrosine phosphorylation of SHC3 and binding to TRKB. Activated EGFR also interacts with and tyrosine-phosphorylates SHC3, inducing an association with GRB2. SHC3 and SCK mediate EGF signaling, but SHC3 has a higher affinity for TRKA and TRKB. (NCI Thesaurus)
YOU MAY ALSO LIKE
Neuronal migration protein doublecortin (402 aa, ~45 kDa) is encoded by the human DCX gene. This protein is involved in neuronal…
A diverse group of congenital brain developmental disorders characterized by defects in neuronal migration in the brain during early fetal development. The…
A group of mostly autosomal recessive inherited neurodegenerative disorders characterized by accumulation of lipofuscin in the neuronal cells and in other tissues…
Widely expressed human NRCAM Gene (L1/Neurofascin/NgCAM Family) encodes alternative isoforms of Neuronal Cell Adhesion Molecule, a cell adhesion ankyrin-binding potential type I…
A group of central nervous system neoplasms with a variable amount of neuronal and, less consistently, glial differentiation. They occur at a…
Neuronal acetylcholine receptor subunit beta-4 (498 aa, ~56 kDa) is encoded by the human CHRNB4 gene. This protein is involved in ion…
