NG-nitro-L-arginine

Pronunciation

Definition 1

A form of the amino acid arginine. An amino acid is a protein building block. NG-nitro-L-arginine is being studied in the treatment of cancer and other conditions. In cancer, it may stop the growth of tumor cells by blocking certain proteins needed for tumor cells to grow and by blocking blood flow to the tumor. It is a type of nitric oxide synthase inhibitor and an antiangiogenesis agent. Also called nitroarginine. (NCI Dictionary)

Definition 2

An amino acid derivative and nitric oxide synthase (NOS) inhibitor with potential antineoplastic and antiangiogenic activities. Upon administration, NG-nitro-L-arginine inhibits the enzyme nitric oxide synthase, thereby preventing the formation of nitric oxide (NO). By preventing NO generation, the vasodilatory effects of NO are abrogated leading to vasoconstriction, reduction in vascular permeability and an inhibition of angiogenesis. As blood flow to tumors is restricted, this may result in an inhibition of tumor cell proliferation. NO plays an important role in tumor blood flow and stimulation of angiogenesis, tumor progression, survival, migration and invasiveness. (NCI Thesaurus)

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