Niacinamide

Pronunciation

Definition 1

A form of niacin (vitamin B3) that the body needs in small amounts to function and stay healthy. Niacinamide is found in many plant and animal products and in dietary supplements. It is water-soluble (can dissolve in water) and must be taken in every day. Niacinamide may be used to treat diabetes and certain skin conditions and is being studied in the treatment of some types of cancer. It may increase blood flow to cancer cells and block certain enzymes they need to repair damage to their DNA. This may make cancer cells easier to kill with radiation therapy and chemotherapy. Niacinamide is a type of radiosensitizing agent and a type of chemosensitizing agent. Also called nicotinamide. (NCI Dictionary)

Definition 2

The active form of vitamin B3 and a component of the coenzyme nicotinamide adenine dinucleotide (NAD). Niacinamide acts as a chemo- and radio-sensitizing agent by enhancing tumor blood flow, thereby reducing tumor hypoxia. This agent also inhibits poly(ADP-ribose) polymerases, enzymes involved in the rejoining of DNA strand breaks induced by radiation or chemotherapy. (NCI Thesaurus)

Definition 3

A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Niacinamide helps some enzymes make energy in the cell. It is found in many plant and animal products. It is water-soluble (can dissolve in water) and must be taken in daily. It is being studied to increase the effect of radiation therapy on tumor cells. (NCI Dictionary)

YOU MAY ALSO LIKE

Niacin-based Antilipidemic Agent

An antilipidemic agent that works through, or mimics, the action of niacin to increase HDL-C levels by blocking hepatic uptake of apolipoprotein…

Niacin

A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Niacin helps some…

Ni2+

Nickel ion requiring two electrons to return to its elemental state.

NHL-BFM-95 Regimen

A modified version of the NHL-BFM 90 regimen, employing a different methotrexate dosing schedule, used for the treatment of localized aggressive forms…

NHL-BFM-90 Regimen

A regimen used for the treatment of localized aggressive forms of childhood B-cell non-Hodgkin's lymphoma, including lymphoblastic lymphoma.

NHL

Any of a large group of cancers of lymphocytes (white blood cells). NHLs can occur at any age and are often marked…