| Health / Medical Topics |
NPM1/RARA Long Fusion Protein
A fusion protein (563 aa, ~63 kDa) encoded by the NPM1/RARA long fusion gene. This protein is comprised of the N-terminus of the nucleophosmin protein fused to the DNA-binding domain, ligand binding domain and coactivator recognition site from the retinoic acid receptor alpha protein. (NCI Thesaurus)
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A fusion gene (~2.1 kb) that results from a chromosomal translocation t(5;17)(q35;q21) which fuses the first 484 nucleotides of the NPM1 gene…
A fusion protein (680 aa, ~75 kDa) that is encoded by the NPM1/ALK fusion gene. This protein contains the N-terminal domain from…
A fusion gene that results from a chromosomal translocation t(2;5)(p23;q35) which fuses the first 4 exons of the NPM1 gene with the…
Human NPM1 wild-type allele is located in the vicinity of 5q35 and is approximately 24 kb in length. This allele, which encodes…
Mutation of the nucleophosmin gene. It is seen in acute myeloid leukemias usually associated with a normal karyotype.
This gene is involved in the regulation of ribosomal assembly.
